6/7/2023 0 Comments Altered skin![]() The nine patients in the trial had a form of epidermolysis bullosa called recessive dystrophic epidermolysis bullosa, or RDEB. The study was funded by Krystal Biotech Inc., which is testing and developing the gel for clinical use. Former research scientist Irina Gurevich, PhD, is the lead author. ![]() Marinkovich, an associate professor of dermatology, is the senior author of the study, published online March 28 in Nature Medicine. The gel is stable at room temperature and can be applied without specialized expertise during routine bandage changes - key advantages for patients worldwide who have difficulty accessing specialized medical care, Marinkovich said. “The therapy strengthens the skin and breaks the painful and destructive cycle of wound opening and closing that patients with epidermolysis bullosa experience.” “The wounds heal quickly but, even more importantly, they stay closed,” said Peter Marinkovich, MD, director of Stanford Medicine’s Blistering Disease Clinic. For one patient, a chronic wound that had persisted for five years closed completely after two successive rounds of treatments and remained closed throughout eight months of monitoring. It is also the first trial of gene therapy in children with epidermolysis bullosa.Ī large 10-year-old wound covering most of the side of a patient’s body showed 70% healing, while all other wounds closed completely with treatment. The trial is the first to show that gene therapy vectors for skin diseases can be effective when applied topically. Rubin, MD.ġ0.2K views| original sound - Dr.A gene therapy gel applied to the wounds of nine people - three of whom were children - with the blistering skin disease epidermolysis bullosa helped the wounds heal and remain healed for several months in a trial headed by researchers at Stanford Medicine. Mechanism of eczema | “Th2 skewing”Eczema mechanisms original sound - Dr. This is why good skin care focusing on moisturizing, reducing environmental and irritant exposure and topical and systemic immunosuppressive medications can be helpful.". ![]() This can lead to transepithelial water loss and inflammation that shows up as dry, itchy, cracked, scaly inflamed skin. Rubin, MD "Replying to Eczema is a complex interplay of skin barrier dysfunction, immune dysregulation and an altered skin microbiome. This is why good skin care focusing on moisturizing, reducing environmental and irritant exposure and topical and systemic immunosuppressive medications can be helpful.ĥ40 Likes, 37 Comments. ![]() Replying to Eczema is a complex interplay of skin barrier dysfunction, immune dysregulation and an altered skin microbiome. skincare products that completely changed my skin (as someone who had severe acne) original sound - Cam. TikTok video from Kristyn Johnson "these products actually altered my skin and helped so much with my acne and texture!□□ The panoxyl completely got rid of my stubborn acne and the other products aided in the appearance if my skin! #howigotridofacne #acnetreatment #acnejourneytoclearskin #acnejourney #howtogetclearskin #panoxyl #panoxylfacewash #acne #acnescars #larocheposay #larocheposayvitaminc #vitamincserum #cerave #greenscreen". These products actually altered my skin and helped so much with my acne and texture!□□ The panoxyl completely got rid of my stubborn acne and the other products aided in the appearance if my skin! #howigotridofacne #acnetreatment #acnejourneytoclearskin #acnejourney #howtogetclearskin #panoxyl #panoxylfacewash #acne #acnescars #larocheposay #larocheposayvitaminc #vitamincserum #cerave #greenscreenģ.4K Likes, 25 Comments.
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